DEPARTMENT OF IMMUNOLOGY AND BIOELECTROCHEMISTRY

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DEPARTMENT OF IMMUNOLOGY AND BIOELECTROCHEMISTRY

Fundamental and applied scientific research, experimental development in immunology, cell culture technologies and immune analysis are implemented in the Department of Immunology and Bioelectrochemistry.

The department specializes on characterization of immunity state in case of pathology, search of the objective biomarkers for diagnostics of diseases and immunotherapy effectiveness monitoring both in vitro and in vivo. Additionally, the department develops various enzymatic biosensors and immunosensors and investigates their practical applications. Another specialization is in the area of cancer treatment and immunology, incl. immunomodulation and cytotoxicity studies (β-glucans, Quinones, Nitroaromatics Flavonoids, Aromatic N-oxides, etc.).

The research of the phenomenon of electroporation is also highly focused, which includes biophysics, modelling, development of technology and expansion of applications of this technique. One of the highly focused applications is electrochemotherapy and tissue ablation using pulsed electric fields, incl. characterization of the immune response following the treatment. Recently, the researchers of the department of Immunology and Bioelectrochemistry presented series of works on the new modality of electroporation, which includes MHz pulse burst compression ensuring significantly improved drug and gene delivery. The competences of the researchers in the department are interdisciplinary, therefore, we can develop high power magnetic and electric field generators tailored for specific needs of the experiments.

Last updated: 2024-11-19, 11:38:23

Useful information

PARTNERS

While doing scientific researches immunology department collaborates with Lithuanian and foreign countries science institutions and business companies. The main Department of Immunology and Bioelectrochemistry partners are:

Vilnius University

National Cancer Institute
Vilnius Gediminas Technical University
Karolinska Institute( Sweden)
August Kirchenstein microbiology and virology Institute (Latvia )
Business companies as Thermo Fisher Scientific Baltics, BIOTECHPHARMA, Biocenter, Innovative Pharma Baltics and others.

10 doctorates are studying in this department.

PhD students

Mickeviciute Egle

2023-10-01 – 2027-09-30

PhD supervisor – prof. dr. Vitalij Novickij

Topic - Impact of high-frequency asymmetric nanosecond electric field sequences for control of tumor drug resistance and elimination.

Cesna Robertas

2020-10-01 – 2025-09-30

PhD supervisor – dr. Giedrius Kalesnykas

Topic - Preclinical age-related macular degeneration analysis: miR-17-5p as VEGF modulator.

Vanagaite-Zickiene Milda

2020-10-01 – 2025-09-30

PhD supervisor – dr. Dainius Characiejus

Topic - Influence of tumor-infiltrating macrophages on tumor cell proliferation.

Zelvys Augustinas

2024-10-01 – 2028-09-30

PhD supervisor – prof. dr. Vitalij Novickij

Topic - Research of contactless cell transmembrane potential induction for controlled drugs and gene delivery.

7 BP:

Immunoglobulin IgY pseudomonas A clinical trial for cystic fibrosis treatment (IMPACTT), (2010-2014)

Lithuania-Latvia-China (Taiwan) collaboration program:

Establishing of the framework to track molecular epidemiology of Parvoviruses and to correlate sequence variability with different clinical manifestations (2012-2014)

Nacional scientific program projects:

Precision next-generation exon sequencing technology for healthy aging in patients with a predisposition to breast and ovarian cancer (2015-2018)
Targeted new sequence for genetic predisposition to breast, ovarian and colon cancer (2012-2014)
Biocontrol of microorganisms activating under microgravity conditions and causing skin infections using electro-magnetoporation (2016-2018)

Scientific groups projects:

Influence of electrochemotherapy and its combination with dendritic cell vaccination on the elimination of fungal tumors and the formation of the immune response (2019-2022)
Non – invasive detection of immunological markers in amniotic fluid during preterm labor (2019-2022)
Research of persistent infection and its association with autoimmune epithelium (2014-2016)

our contacts

Department of Immunology and Bioelectrochemistry